Mechanism of Action
We believe Autem EM fields cause cancer cell division disruption, intracellular ionic kinetics interference and metabolic alterations, inhibiting tumor growth.
What is electromagnetic field and electromagnetic induction and resonance?
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Electromagnetic fields
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Electromagnetic induction
An electromagnetic field is a common and natural force that surrounds us all the time. It is the combination of an invisible electric field, produced by stationary charges, and a magnetic field, produced by moving charges (currents). It is one of the four fundamental forces of nature.
One of the phenomena of electromagnetic fields is electromagnetic induction, which is the appearance of electric current in a conductor immersed in an electromagnetic field. Another phenomenon of electromagnetic fields is resonant coupling, which occurs when the natural frequencies of the two systems – a source and a receiver — are approximately the same.
Through this physical process, studies of Nikolas Tesla in the late 19th century, and recently studies done by MIT, show how to transfer wireless energy. (See more on TED Global – Wireless Electricity)
Autem’s technology uses the same physical principle of electromagnetic induction and resonance by using specific electromagnetic radiation to send a signal to the cancer cells. Similar to the conductor immersed in an electromagnetic field, the human body functions as an antenna of this specific signal, and because the radiation is modulated at patient-specific frequencies, only the cancer cells are targeted by this type of induction and resonance signal.
Application of Autem EM fields to the human body
The carrier frequency can be modulated in amplitude at specific and very low frequencies. Mobile phone telecommunications use a carrier radiofrequency band in 27.12 MHz.
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Modulation frequency at patient-specific frequencies (PSF) at very-low range
Cancer-specific modulation frequencies from 100 Hz to 21 kHz.
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Carrier frequency
27.12 MHz
The amplitude modulation signal (enveloped frequency) is transferred to the entire human body, without causing tissue heat or electric current, by a stainless-steel spoon-shaped RF applicator. It is applied orally to deliver energy to the whole body.
The human body becomes an antenna and the energy is systemically distributed. The device emits 10 times lower energy then a mobile phone.
Physiological responses identify patient-specific frequencies – PSF
Heart rate variability (HRV) refers to non-linear alteration in beat-to beat intervals. High precision hemodynamic monitor continuously record the hemodynamic activity for frequency-domain or time-domain analysis. Changing the hemodynamic variability, the human body reacts to patient-specific modulated frequencies.
Computing processes can identify patient-specific frequencies of modulation registered among each patient, independent of the cancer type by mean hemodynamic changes. This autonomous response is different among healthy controls and cancer patients.
Subcellular mechanism of action of the Autem EMfields
Electromagnetic field (EMF) gradients, especially in dividing cells, cause substantial dielectrophoretic forces on tubulin dimers, microtubules (MTs) and mitochondria. EMF also causes disruption of the mitotic spindle in cancer cells during mitosis. Modulation frequencies cause coherent resonant modulation of MTs and mitochondria.
The oscillation signals cause a series of downstream effects:
- alteration of dynamics of ion channels
- ionic waves conduction along MTs and possibly actin filaments
- alterations in motor protein motions
- general effect of net charge of the cytoplasm
- alterations in cellular metabolism
Cell morphology differences, MT length and mitochondrial oscillation variability could explain different cellular responses and cancer cell specificity.
Disruption of the mitotic spindle
Hydropic degeneration
Another believed effect of the action of the Autem EM fields at patient specific frequencies (PSF) is the hydropic degeneration of the cancer cells. Coherent resonance of the modulated frequencies leads to an alteration in the ionic kinetic of the ion channels on cell membrane, conducting to an electric intracellular disfunction, alteration in intracellular metabolism and hydropic degeneration, followed by instant cell death.
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Ultrastructure changes observed in neoplastic cells after Autem EM fields in two different patients. In both images, the cells show marked cytoplasmic hydropic expansion with disruption of cytosolic structures and a dilation of reticulum.
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Ultrastructure changes observed in two different patients not submitted to Autem EM fields (controls).
Antiproliferative effects
Tumor over size
Antiproliferative effects in cancer cells and animals with xenografted tumors
Antitumor efficacy was demonstrated in cancer cell culture and xenograft models. Alteration of the IP3/DAG signaling pathway exclusively in cancer cells. Inflow of calcium mediated by T-type calcium channels in cancer cells.
Antiproliferative effect was observed by reduction in Ki-67 and cyclin D1
Huh7 cells xenografts were treated for 6 weeks with HCC-specific RF EMF before sacrifice. Significant antitumor effect was observed in residual tumor. No toxic cellular effect in lung, small intestine and kidney tissues.
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