Treatment Indications

HCC unmet medical need

What is hepatocellular carcinoma (HCC)?

A cancer arising from the liver cells (hepatocytes). Liver damage, manifested by cirrhosis (scarring), is a primary risk factor for liver cancer. Cirrhosis may be caused by viral hepatitis, primarily hepatitis B and C, alcohol abuse, hemochromatosis, certain autoimmune diseases of the liver, and other diseases that result in chronic inflammation of the liver.

Ferlay J et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015,136:E359-86; Ferlay J et al. Global Cancer Statistics. Ca Cancer J Clin 2011, 61:69–90; Siegel R et al. Cancer Statistics, 2017. Ca Cancer J Clin 2017, 67:7–30; Siegel R et al. Trends in colorectal cancer incidence rates in the United States by tumor location and stage, 1992-2008. Cancer Epidemiol Biomarkers Prev. 2012, 21:411-416; McGlynn K et al. The Global Epidemiology of Hepatocellular Carcinoma, Present and Future Clin Liver Dis. 2011,15,223-x

The sixth most common cancer worldwide
749,000 new cases/year

In 2017, US estimated new cases for liver cancer is 40.710

Third cause of cancer related death worldwide
692,000 cases/year

Accounts for 7% of all cancers worldwide

40% of them have poor liver function – not eligible for standard treatment

50% are diagnosed with advanced disease – incurable disease

Systemic treatment in patients with advanced disease cause quality of life deterioration